Glucocorticoid use as a cause of non-cellular immune response to SARS-Cov2 Spike in patients with immune system diseasesArticle Published on 2022-12-012023-07-10 Journal: Journal of autoimmunity [Category] COVID19(2023년), [키워드] antibody COVID-19 Glucocorticoids IGRA immune system diseases multiple sclerosis sarcoidosis spike systemic lupus erythematosus vasculitis. [DOI] 10.1016/j.jaut.2022.102912 PMC 바로가기
Corticosteroids: A boon or bane for COVID-19 patients?Article Published on 2022-12-012022-10-27 Journal: Steroids [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료제, [키워드] Corticosteroids COVID-19 Glucocorticoids Remdesivir Repurposed drugs [DOI] 10.1016/j.steroids.2022.109102
Pharmacological treatment in pregnant women with moderate symptoms of coronavirus disease 2019 (COVID-19) pneumoniaArticle Published on 2022-12-012023-07-06 Journal: The journal of maternal-fetal & neonatal medicine [Category] COVID19(2023년), [키워드] gestation Glucocorticoids oligohydramnios remdesivir. SARS-CoV-2 [DOI] 10.1080/14767058.2021.1903426 PMC 바로가기
New insights into development and mortality of COVID-19-associated pulmonary aspergillosis in a homogenous cohort of 1161 intensive care patientsArticle Published on 2022-11-012022-11-15 Journal: Mycoses [Category] 진단, [키워드] acute respiratory distress acute respiratory distress syndrome analysed ARDS Cohort collected Computed tomography consolidation COVID-19-associated pulmonary aspergillosis defined development diabete diabetes disease distress Factor Fever Glucocorticoid treatment Glucocorticoids hemoptysis high mortality homogenous hospitalised immune dysregulation intensive care patient laboratory data large cohort lung lesion lymphopenia Mortality mortality. multivariable analysis Multivariable models neutrophilic leukocytosis New nodule Odds ratio pathology Patient Prevalence pulse reported syndrome the disease univariable [DOI] 10.1111/myc.13485 PMC 바로가기
Humoral immune response against BNT162b2 mRNA COVID-19 vaccine in patients with rheumatic disease undergoing immunosuppressive therapy: A Japanese monocentric studyArticle Published on 2022-10-212022-11-15 Journal: Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome addition Analysis analyzed Antibody titer attenuate Baricitinib BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 vaccine Combination controls coronavirus coronavirus disease COVID-19 COVID-19 vaccine disease domain dose Glucocorticoids healthy volunteer humoral immune response immunomodulatory Immunosuppressant immunosuppressants immunosuppressive immunosuppressive agent Immunosuppressive medication impair inhibitor inhibitors interleukin-17 interleukin-6 investigated Japanese Kagawa methotrexate much lower Necrosis of BNT162b2 Outpatient Patient patients treated reduced rheumatic disease SARS-CoV-2 SARS-CoV-2 spike protein second dose serum serum antibody significantly significantly lower Spike protein the patient therapeutic agent Treatment university Vaccine [DOI] 10.1097/MD.0000000000031288 PMC 바로가기
Multi-Omics Reveals Mechanisms of Partial Modulation of COVID-19 Dysregulation by Glucocorticoid TreatmentArticle Published on 2022-10-112022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] acquisition Amino acid analysed Analysis arginine caused Cohort Concentration COVID-19 COVID-19 infection COVID-19 infections COVID-19 pathogenesis dataset degranulation Dexamethasone dysregulation effective feature glucocorticoid Glucocorticoid treatment Glucocorticoids Guidance highlight include indicated Interaction mass spectrometry metabolomics modulation mortality rates Multi-omics neutrophil oxygen supplementation pandemic Partial participant pathway Pathway analysis Patient Platelet proteomics proteomics. Quantitative serum statistically significant Treatment treatment regimen tyrosine was performed [DOI] 10.3390/ijms232012079 PMC 바로가기
New Insights on Effects of Glucocorticoids in Patients With SARS-CoV-2 InfectionReview Published on 2022-10-012023-07-10 Journal: Endocrine practice : official journal of the American College of [Category] COVID19(2023년), [키워드] Anti-inflammatory effects COVID-19 Glucocorticoids hyperinflammatory syndrome. [DOI] 10.1016/j.eprac.2022.07.006 PMC 바로가기 [Article Type] Review
Could Endogenous Glucocorticoids Influence SARS-CoV-2 Infectivity?Article Published on 2022-09-212022-11-15 Journal: Cells [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 (angiotensin converting enzyme 2) Affect alteration analogues Antiviral component conformational coronavirus coronavirus diseases cortisol COVID-19 Deleterious Dexamethasone endogenous enzyme glucocorticoid Glucocorticoids groups Host Immunological disorders Infection influence inhibit SARS-CoV-2 Innate immunity Interaction mechanism outcome pathogen produced PROTECT Protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Signal transduction spike Spike protein spike protein. stimulate subunit surface protein target cells variant [DOI] 10.3390/cells11192955 PMC 바로가기
Clinical course of Covid-19 in a cohort of patients with Behçet diseaseResearch article Published on 2022-09-012022-10-05 Journal: Medicina clínica [Category] 임상, [키워드] age Ageusia Behçet disease clinical Clinical outcome clinical outcomes clinical symptom cohort of patient Colchicine conducted Continuous Course COVID-19 demographics disease dose Dyspnea General population glucocorticoid Glucocorticoids implication Infection inhibitor long-term treatment Medical conditions Necrosis no significant difference objective Patient patients Prevalence provided questionnaire reduced Result Retrospective study significantly higher Spain tested therapeutic agent therapy Tumor necrosis factor alpha inhibitor [DOI] 10.1016/j.medcli.2021.11.009 [Article Type] Research article
Immunosuppressed non-responders to two doses of mRNA SARS-CoV-2 vaccines achieve an immune response comparable to those of immunocompetent individuals after a third doseArticle Published on 2022-09-012022-11-15 Journal: Hormones (Athens, Greece) [Category] COVID19(2023년), SARS, 진단, [키워드] anti-CD20 antibody response against Antibody titer appear Autoimmune disorders cancers cascade cell-mediated immune comparable disease dose elevated Glucocorticoids Hematological malignancies immune response Immunocompromised Immunosuppressed Immunosuppression individual induce inhibitor methotrexate MMF monoclonal antibody MOST mRNA mRNA SARS-CoV-2 vaccines. neutralizing antibody non-responder Patient proportion Protein Rapamycin recipient S protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines Signaling solid cancers solid organ transplant suggested the SARS-CoV-2 the SARS-CoV-2 virus third dose transplantation Treatment Vaccine Vaccines variety while [DOI] 10.1007/s42000-022-00365-y PMC 바로가기